Shang, Yang. The Book of Lord Shang. A Classic of the Chinese School of Law. Translated from the Chinese with Introduction and Notes by Dr. J.J.L. Duyvendak.

Plato's theory of knowledge and belief is an important topic in Platonic scholarship. There are at least two interpretations of Plato's theory of knowledge and belief. (a) The two worlds (or objects) interpretation (TW), and it has two versions: the degree of existence interpretation (DE) and the degree of reality interpretation (DR). According to DE, objects of knowledge fully exist, and objects of belief do not fully exist. According to DR, objects of knowledge are fully real, and objects of belief (...) are not fully real. The main claim of TW is: knowledge and belief range over different objects; knowl­edge ranges over Forms,·and belief ranges over the sensibles. This claim implies that we can have knowledge only of Forms, and belief only of the sensibles. The second interpretation of Plato's theory is b), the content interpretation. There are two versions of the content interpretation. First, there is the degrees of truth (DT) or individual truth version: Knowledge is set over truth, and belief is set over partial truth. Second, there is Fine's collective truth version (CT). The main claim of CT is that: knowledge collects truths (i.e., knowledge entails truth), and that belief collects truths and falsehoods (i.e., some beliefs are true and some are false). This claim implies that knowledge and belief are not always set over different things, i.e., we can have knowledge of the sensibles, and beliefs of Forms. TW is obviously incompatible with CT. It is surprising that little defense of TW has been given following Fine's objection to TW. In this paper, TW will be defended, and it will be argued that CT is not a correct reading of Plato. (shrink)

Decision-making competence refers to the ability to make better decisions, as defined by decision-making principles posited by models of rational choice. The adult decision-making competence (A-DMC) scale is a relatively mature evaluation tool used for decision-making competence. However, the A-DMC is yet far from other mature psychological evaluation tools, and especially the structure of A-DMC remains unclear. In the current study, we estimated a regularized partial correlation network of decision-making competence in a Chinese sample consisting of 339 adults who were (...) evaluated by the A-DMC, and then the centrality indicators were calculated. The results revealed that all nodes of the decision-making competence networks are positively associated, except for the association of resistance to framing (RF) and resistance to sunk costs (SC). The strongest edge was between RF and applying decision rules (DR; regularized partial correlation = 0.37). The centrality indicators of RF and applying DR were highest, revealing that these two variables may play important roles in the decision-making competence network. Our study conceptualizes the decision-making competence from network perspectives, so as to provide some insights for future researches. (shrink)

Buku yang ditulis oleh Dr. A. Setyo-Wibowo (SW) dan Haryanto Cahyadi, M. Hum. (HC), dua-duanya dosen filsafat, yang satu di Jakarta, yang satu di Jayapura, ini betul-betul memperkaya pustaka tentang filsafat dalam bahasa Indonesia. Platon tetap salah satu filosof terbesar, kalau bukan filosof terbesar segala zaman. Dalam buku ini para penulis mengantar pembaca ke jantung filsafat Platon. Mereka melakukannya dengan membawa pembaca ke dalam teks-teks kunci Platon. Yang mereka angkat adalah pemikiran Platon tentang pendidikan. Pendidikan bukan (...) salah satu bidang pemikiran Platon, melainkan intinya. Seluruh filsafat Platon, seperti setiap filsafat sejati, akhirnya hanya punya satu tujuan: ia mau mencerahkan. Ya mencerahkan kita. Menunjukkan ke mana kita harus mengarahkan dan mengembangkan kita agar kita menjadi manusia yang mutu. Buku ini membuat kita betul-betul mengerti Platon, tidak hanya seperti dalam buku-buku “ringkasan sejarah filsafat”, melainkan secara mendalam. Namun buku SW dan HC ini mempunyai nilai lebih. Mereka tidak hanya membawa kita ke Platon, melainkan mengangkat aktualitas pemikirannya. Platon mau mendidik pemimpin negara. Ia tidak berfilsafat dalam udara kosong, melainkan pada zaman di mana demokrasi Athena sudah kacau balau karena disandera oleh elit-elit korup. Dalam situasi ini Platon mengembangkan konsepsinya tentang suatu pendidikan yang bisa melahirkan pemimpin negara yang baik. SW dan HC menunjukkan bahwa pemikiran Platon 2500 tahun lalu sekarang di Indonesia pun masih pantas diperhatikan. Buku ini bukan bacaan gampang. Uraiannya tidak secara esai omongan ringan, melainkan betul-betul ngilmu, memakai metode-metode analisa filosofis, mengutip dari teks-teks Platon sendiri, dengan mengacu pada pustaka para ahli Platon yang state of the art. Bahasa pun tidak menggampangkan. Untuk tetap rapat dengan teks, mereka suka memakai kata-kata kunci dalam bahasa Yunani. Ambil misalnya judul ini: "Paideia Kaum Sofis: Penciutan Aisthesis-Arete dan Dominasi 'Empeiria'". Pembaca mana langsung akan tahu apa kiranya akan dibahas. Pembaca barangkali sering harus mencari dalam daftar istilah (yang, sayang, tidak lengkap) apa arti suatu kata, misalnya logistikon atau Iliados, kemudian lupa lagi, cari lagi dst. Tetapi bagi pembaca yang bertahan ganjarannya besar. Ia akan masuk ke dalam pemikiran Platon yang asli, rinci, sangat menarik...................... Masih satu catatan tentang cita-cita manusia yang kaloskagathos, elok nan baik. Membaca uraian bagus para penulis saya terdorong untuk bertanya apakah bukan sudah waktunya cita-cita Yunani kuno yang dalam etika kontemporer sama sekali hilang itu perlu diangkat kembali. Paham manusia mutu sebagai manusia elok nan baik berhasil melepaskan etika dari moralisme sempit (searah dengan MacIntyre – After Virtue – yang mengangkat kembali paham "keutamaan" Yunani yang kuat dan utuh terhadap paham mandul-moralistik istilah "keutamaan" dalam budaya Barat). Begitu pula etika Jawa memahami kebaikan manusia yang mantap dan utuh dalam keterkaitan antara kebaikan etis dan kebaikan estetik. - Catatan kecil: Dalam indeks seharusnya tidak dimuat nama yang terdapat dalam daftar pustaka. Buku Setyo Wibowo dan Haryanto Cahyadi ini bukan hanya pandu kompeten ke jantung filsafat Platon, melainkan memberikan rangsangan-rangsangan baru untuk pemikiran filosofis. (Franz Magnis-Suseno, Program Pascasarjana, Sekolah Tinggi Filsafat Driyarkara, Jakarta). (shrink)

Background Community advisory boards have expanded beyond high-income countries and play an increasing role in low- and middle-income country research. Much research has examined CABs in HICs, but less is known about CABs in LMICs. The purposes of this scoping review are to examine the creation and implementation of CABs in LMICs, including identifying frequently reported challenges, and to discuss implications for research ethics. Methods We searched five databases for publications describing or evaluating CABs in LMICs. Two researchers independently reviewed (...) articles for inclusion. Data related to the following aspects of CABs were extracted from included publications: time, country, financial support, research focus, responsibilities, and challenges. Thematic analyses were used to summarize textual data describing challenges. Results Our search yielded 2005 citations, 83 of which were deemed eligible for inclusion. Most studies were published between 2010 and 2017. Upper-middle-income countries were more likely to have studies describing CABs, with South Africa, China, and Thailand having the greatest numbers. The United States National Institutes of Health was the main source of financial support for CABs. Many CABs focused on HIV research. Thirty-four studies reported how CABs influenced the informed consent process for clinical trials or other aspects of research ethics. CAB responsibilities were related to clinical trials, including reviewing study protocols, educating local communities about research activities, and promoting the ethical conduct of research. Challenges faced by CABs included the following: incomplete ethical regulations and guidance; limited knowledge of science among members of communities and CABs; unstable and unbalanced power relationships between researchers and local communities; poor CAB management, including lack of formal participation structures and absence of CAB leadership; competing demands for time that limited participation in CAB activities; and language barriers between research staff and community members. Several challenges reflected shortcomings within the research team. Conclusions Our findings examine the formation and implementation of CABs in LMICs and identify several ethical challenges. These findings suggest the need for further ethics training among CAB members and researchers in LMICs. (shrink)

ObjectiveThe present study aimed to identify and analyze the bibliometric characteristics of the 100 top-cited studies on neuropsychology.MethodsWe searched the Web of Science Core Collection database to collect studies on neuropsychology from inception to 31st December 2019. Two authors independently screened the literature and extracted the data. Statistical analyses were performed using R software.ResultsThe 100 top-cited articles were cited a total of 166,123 times, ranging from 736 to 24,252 times per article. All of the studies were published from 1967 to (...) 2014 in 47 journals. Neuropsychologia had the highest number of articles, followed by Neurology. The top three most productive countries were the USA, England, and Canada. Eight authors contributed the same number of studies as the first author or corresponding author. The most productive institute was the University of California, followed by the University of Pennsylvania. Of the 100 top-cited publications, 64 were original articles, and 36 were reviews. The top three Web of Science categories were clinical neurology, behavioral sciences, and psychiatry.ConclusionThis study provides insight into the impact of neuropsychology research and may help doctors, researchers, and stakeholders to achieve a more comprehensive understanding of trends and most influential contributions to the field, thus promoting ideas for future investigation. (shrink)

A gourd is a sort of pumpkin whose shell is frequently used to keep food and water. Gourds are also used as kitchen utensils, musical instruments or decoration. This paper draws attention to the time framework in gourd image representations, which symbolize universality and immortality as well as the positive notions of regeneration and emptiness. By analyzing the artistic expressions in the form of gourd representations reflected in literature and art, this paper reveals the complex notion of time in Chinese (...) civilization. (shrink)

George Ohsawa's account of his 1955 visit to Dr. Albert Schweitzer's hospital in Africa and how he discovers a cure for deadly tropical ulcers followed by his teachings on the physical and mental aspects of disease, the traditional approach to healing versus the symptomatic medicine of today, and the priniciple of the unifying principle of yin and yang--the foundation of macrobiotics.

Although there have been numerous studies on mental wellbeing impairment or other negative consequences of Workplace Violence (WPV) against healthcare professionals, however, the effects of WPV are not limited to those who experience WPV in person, but those who exposed to WPV information indirectly. In the aftermath of “death of Dr. Yang Wen,” a cross-sectional study was conducted to explore the psychological status of healthcare professionals. A total of 965 healthcare professionals from 32 provinces in China participated in our (...) research. The prevalence rates of Post-Traumatic Stress Disorder (PTSD) symptoms, depression, anxiety among healthcare professional in the current study were 25.60, 46.01, and 27.88%, respectively. Moreover, our research suggested that the awareness of WPV-incident had a significant association with PTSD symptoms. In addition, risk perception was shown to mediate the effect of WPV awareness on PTSD symptoms. Furthermore, the present research also found a U-shaped relationship between issue salience and PTSD symptoms, and the relationship between issue salience and anxiety, indicating that higher awareness of WPV issue was negatively related to mental health status (including PTSD and anxiety) but only to the points at which there were no additional effects of more issue salience. This study highlighted that more protective measures for healthcare professionals need to be implemented in response to potential WPV events. More importantly, risk perception was found to mediate the effect of WPV issue salience on PTSD symptoms, it is critical to reduce the mental health burden through intervening in risk perception. (shrink)

The article will be divided into three parts: 1. Explain the literary origins of the nesting pattern and its relationship to cinema narrative, and analyse the nesting tactics commonly used in films under Hollywood’s classical narrative. 2. Describe the variations in nested structures in films made in the 1990s, focusing on self-reflexive nesting, which emerged as a new model beyond conventional nesting during this period. 3. Distinguish the literary style of embedded narratives from the visual recognition mode and provide an (...) example of how the latter is used in films to create impossible puzzles. (shrink)

This study investigates the sampled-data admissibility problem for a singular system. The objective of this paper is to design a sampled-data controller to ensure the admissibility of a singular system and to construct an appropriate Lyapunov–Krasovskii functional to get less conservative results for the sampled-data singular system. To accomplish these objectives, the system is converted into a time-delay system by the input delay approach firstly, and both lower and upper bounds of the delay are considered. Secondly, by introducing a suitable (...) LKF, the admissibility criteria are obtained. Then, when estimating the derivative of the LKF, a relaxation variable is introduced by the method of reciprocally convex inequality, and it is proved that the conservatism is reduced. Finally, two numerical examples are given to prove that the designed sampled-data controller can ensure the states of the systems under the influence of external interference. (shrink)

ABSTRACT I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments. INTRODUCTION In contrast to the classic model of randomized-control trials, often with a large number of (...) subjects enrolled, precision medicine attempts to optimize therapeutic outcomes by focusing on the individual.[i] A recent publication highlights the strengths and weakness of both traditional evidence-based medicine and precision medicine.[ii] Plus, it outlines a tension in the shift from evidence-based medicine’s inductive reasoning style (the collection of data to postulate general theories) to precision medicine’s abductive reasoning style (the generation of an idea from the limited data available).[iii] The paper’s main example is the application of precision medicine for the treatment of cancer.[iv] I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. As the name suggests, brain-computer interfaces are a significant advancement in neurotechnology that directly connects someone’s brain to external or implanted devices.[v] Among the various kinds of brain-computer interfaces, adaptive deep brain stimulation devices require numerous personalized adjustments to their settings during the implantation and computation stages in order to provide adequate relief to patients with treatment-resistant disorders. What makes these devices unique is how adaptive deep brain stimulation integrates a sensory component to initiate the stimulation. While not commonly at the level of sophistication as self-supervising or generative large language models,[vi] they currently allow for a semi-autonomous form of neuromodulation. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments.[vii] ANALYSIS I. The State of Precision Medicine in Oncology and the Epistemological Shift While a thorough overview of precision medicine for the treatment of cancer is beyond the scope of this article, its practice can be roughly summarized as identifying clinically significant characteristics a patient possesses (e.g., genetic traits) to land on a specialized treatment option that, theoretically, should benefit the patient the most.[viii] However, in such a practice of stratification patients fall into smaller and smaller populations and the quality of evidence that can be applied to anyone outside these decreases in turn.[ix] As inductive logic helps to articulate, the greater the number of patients that respond to a particular therapy the higher the probability of its efficacy. By straying from this logical framework, precision medicine opens the treatment of cancer to more uncertainty about the validity of these approaches to the resulting disease subcategories.[x] Thus, while contemporary medical practices explicitly describe some treatments as “personalized”, they ought not be viewed as inherently better founded than other therapies.[xi] A relevant contemporary case of precision medicine out of Norway focuses on the care of a patient with cancer between the ventricles of the heart and esophagus, which had failed to respond to the standard regimen of therapies over four years.[xii] In a last-ditch effort, the patient elected to pay out-of-pocket for an experimental immunotherapy (nivolumab) at a private hospital. He experienced marked improvements and a reduction in the size of the tumor. Understandably, the patient tried to pursue further rounds of nivolumab at a public hospital. However, the hospital initially declined to pay for it given the “lack of evidence from randomised clinical trials for this drug relating to this [patient’s] condition.”[xiii] In rebuttal to this claim, the patient countered that he was actually similar to a subpopulation of patients who responded in “open‐label, single arm, phase 2 studies on another immune therapy drug” (pembrolizumab).[xiv] Given this interpretation of the prior studies and the patient’s response, further rounds of nivolumab were approved. Had the patient not had improvements in the tumor’s size following a round of nivolumab, then pembrolizumab’s prior empirical evidence in isolation would have been insufficient, inductively speaking, to justify his continued use of nivolumab.[xv] The case demonstrates a shift in reasoning from the traditional induction to abduction. The phenomenon of ‘cancer improvement’ is considered causally linked to nivolumab and its underlying physiological mechanisms.[xvi] However, “the weakness of abductions is that there may always be some other better, unknown explanation for an effect. The patient may for example belong to a special subgroup that spontaneously improves, or the change may be a placebo effect. This does not mean, however, that abductive inferences cannot be strong or reasonable, in the sense that they can make a conclusion probable.”[xvii] To demonstrate the limitations of relying on the abductive standard in isolation, commentators have pointed out that side effects in precision medicine are hard to rule out as being related to the initial intervention itself unless trends from a group of patients are taken into consideration.[xviii] As artificial intelligence (AI) assists the development of precision medicine for oncology, this uncertainty ought to be taken into consideration. The implementation of AI has been crucial to the development of precision medicine by providing a way to combine large patient datasets or a single patient with a large number of unique variables with machine learning to recommend matches based on statistics and probability of success upon which practitioners can base medical recommendations.[xix] The AI is usually not establishing a causal relationship[xx] – it is predicting. So, as AI bleeds into medical devices, like brain-computer interfaces, the same cautions about using abductive reasoning alone should be carried over. II. Responsive Neurostimulation, AI, and Personalized Medicine Like precision medicine in cancer treatment, computer-brain interface technology similarly focuses on the individual patient through personalized settings. In order to properly expose the intersection of AI, precision medicine, abductive reasoning, and implantable neurotechnologies, the descriptions of adaptive deep brain stimulation systems need to deepen.[xxi] As a broad summary of adaptive deep brain stimulation, to provide a patient with the therapeutic stimulation, a neural signal, typically referred to as a local field potential,[xxii] must first be detected and then interpreted by the device. The main adaptive deep brain stimulation device with premarket approval, the NeuroPace Responsive Neurostimulation system, is used to treat epilepsy by detecting and storing “programmer-defined phenomena.”[xxiii] Providers can optimize the detection settings of the device to align with the patient’s unique electrographic seizures as well as personalize the reacting stimulation’s parameters.[xxiv] The provider adjusts the technology based on trial and error. One day machine learning algorithms will be able to regularly aid this process in myriad ways, such as by identifying the specific stimulation settings a patient may respond to ahead of time based on their electrophysiological signatures.[xxv] Either way, with AI or programmers, adaptive neurostimulation technologies are individualized and therefore operate in line with precision medicine rather than standard treatments based on large clinical trials. Contemporary neurostimulation devices are not usually sophisticated enough to be prominent in AI discussions where the topics of neural networks, deep learning, generative models, and self-attention dominate the conversation. However, implantable high-density electrocorticography arrays (a much more sensitive version than adaptive deep brain stimulation systems use) have been used in combination with neural networks to help patients with neurologic deficits from a prior stroke “speak” through a virtual avatar.[xxvi] In some experimental situations, algorithms are optimizing stimulation parameters with increasing levels of independence.[xxvii] An example of neurostimulation that is analogous to the use of nivolumab in Norway surrounds a patient in the United States who was experiencing both treatment-resistant OCD and temporal lobe epilepsy.[xxviii]Given the refractory nature of her epilepsy, implantation of an adaptive deep brain stimulation system was indicated. As a form of experimental therapy, her treatment-resistant OCD was also indicated for the off-label use of an adaptive deep brain stimulation set-up. Another deep brain stimulation lead, other than the one implanted for epilepsy, was placed in the patient’s right nucleus accumbens and ventral pallidum region given the correlation these nuclei had with OCD symptoms in prior research. Following this, the patient underwent “1) ambulatory, patient-initiated magnet-swipe storage of data during moments of obsessive thoughts; (2) lab-based, naturalistic provocation of OCD-related distress (naturalistic provocation task); and (3) lab-based, VR [virtual reality] provocation of OCD-related distress (VR provocation task).”[xxix] Such signals were used to identify when to deliver the therapeutic stimulation in order to counter the OCD symptoms. Thankfully, following the procedure and calibration the patient exhibited marked improvements in their OCD symptoms and recently shared her results publicly.[xxx] In both cases, there is a similar level of abductive justification for the efficacy of the delivered therapy. In the case study in which the patient was treated with adaptive deep brain stimulation, they at least had their neural activity tested in various settings to determine the optimum parameters for treatment to avoid them being based on guesswork. Additionally, the adaptive deep brain stimulation lead was already placed before the calibration trials were conducted, meaning that the patient had already taken on the bulk of the procedural risk before the efficacy could be determined. Such an efficacy test could have been replicated in the first patient’s cancer treatment, had it been biopsied and tested against the remaining immunotherapies in vitro. Yet, in the case of cancer with few options, one previous dose of a drug that appeared to work on the patient may justify further doses. However, as the Norwegian case presents, corroboration with known responses to a similar drug (from a clinical trial) could be helpful to validate the treatment strategy. (It should be noted that both patients were resigned to these last resort options regardless of the efficacy of treatment.) There are some elements of inductive logic seen with adaptive deep brain stimulation research in general. For example, abductively the focus could be that patient X’s stimulation parameters are different from patient Y’s and patient Z’s. In contrast, when grouped as subjects who obtained personalized stimulation, patients X, Y, and Z demonstrate an inductive aspect to this approach’s safety and/or efficacy. The OCD case holds plenty of abductive characteristics in line with precision medicine’s approach to treating cancer and as more individuals try the method, there will be additional data. With the gradual integration of AI into brain-computer interfaces in the name of efficacy, this reliance on abduction will continue, if not grow, over time. Moving forward, if a responsive deep brain stimulation treatment is novel and individualized (like the dose of nivolumab) and there is some other suggestion of efficacy (like clinical similarities to other patients in the literature), then it may justify insurance coverage for the investigative intervention, absent other unrelated reasons to deny it. III. Ethical Implications and Next Steps While AI’s use in oncology and neurology is not yet as prominent as its use in other fields (e.g., radiology), it appears to be on the horizon for both.[xxxi] AI can be found in both the functioning of the neurotechnologies as well as the implementation of precision medicine. The increasing use of AI may serve to further individualize both oncologic and neurological therapies. Given these implications and the handful of publications cited in this article, it is important to have a nuanced evaluation of how these treatments, which heavily rely on abductive justification, ought to be managed. The just use an abductive approach may be difficult as AI infused precision medicine is further pursued. At baseline, such technology relies on a level of advanced technology literacy among the general public and could exclude populations who lack access to basic technological infrastructure or know-how from participation.[xxxii] Even among nations with adequate infrastructure, as more patients seek out implantable neurotechnologies, which require robust healthcare resources, the market will favor patient populations that can afford this complex care.[xxxiii] If patients already have the means to pay for an initial dose/use of a precision medicine product out of pocket, should insurance providers be required to cover subsequent treatments?[xxxiv] That is, if a first dose of a cancer drug or a deep brain stimulator over its initial battery life is successful, patients may feel justified in having the costs of further treatments covered. The Norwegian patient’s experience implies there is a precedent for the idea that some public insurance companies ought to cover successful cancer therapies, however, insurance companies may not all see themselves as obligated to cover neurotechnologies that rely on personalized settings or that are based on precision/abductive research more than on clinical trials. CONCLUSION The fact that the cases outlined above rely on abductive style of reasoning implies that there may not be as strong a justification for coverage by insurance, as they are both experimental and individualized, when compared to the more traditional large clinical trials in which groups have the same or a standardized protocol (settings/doses). If a study is examining the efficacy of a treatment with a large cohort of patients or with different experimental groups/phases, insurance companies may conclude that the resulting symptom improvements are more likely to be coming from the devices themselves. A preference for inductive justification may take priority when ruling in favor of funding someone’s continued use of an implantable neurostimulator. There are further nuances to this discussion surrounding the classifications of these interventions as research versus clinical care that warrant future exploration, since such a distinction is more of a scale[xxxv] than binary and could have significant impacts on the “right-to-try” approach to experimental therapies in the United States.[xxxvi] Namely, given the inherent limitations of conducting large cohort trials for deep brain stimulation interventions on patients with neuropsychiatric disorders, surgically innovative frameworks that blend abductive and inductive methodologies, like with sham stimulation phases, have traditionally been used.[xxxvii] Similarly, for adaptive brain-computer interface systems, if there are no large clinical trials and instead only publications that demonstrate that something similar worked for someone else, then, in addition to the evidence that the first treatment/dose worked for the patient in question, the balance of reasoning would be valid and arguably justify insurance coverage. As precision approaches to neurotechnology become more common, frameworks for evaluating efficacy will be crucial both for insurance coverage and for clinical decision making. ACKNOWLEDGEMENT This article was originally written as an assignment for Dr. Francis Shen’s “Bioethics & AI” course at Harvard’s Center for Bioethics. I would like to thank Dr. Shen for his comments as well as my colleagues in the Lázaro-Muñoz Lab for their feedback. - [i] Jonathan Kimmelman and Ian Tannock, “The Paradox of Precision Medicine,” Nature Reviews. Clinical Oncology 15, no. 6 (June 2018): 341–42, https://doi.org/10.1038/s41571-018-0016-0. [ii] Henrik Vogt and Bjørn Hofmann, “How Precision Medicine Changes Medical Epistemology: A Formative Case from Norway,” Journal of Evaluation in Clinical Practice 28, no. 6 (December 2022): 1205–12, https://doi.org/10.1111/jep.13649. [iii] David Barrett and Ahtisham Younas, “Induction, Deduction and Abduction,” Evidence-Based Nursing 27, no. 1 (January 1, 2024): 6–7, https://doi.org/10.1136/ebnurs-2023-103873. [iv] Vogt and Hofmann, “How Precision Medicine Changes Medical Epistemology,” 1208. [v] Wireko Andrew Awuah et al., “Bridging Minds and Machines: The Recent Advances of Brain-Computer Interfaces in Neurological and Neurosurgical Applications,” World Neurosurgery, May 22, 2024, S1878-8750(24)00867-2, https://doi.org/10.1016/j.wneu.2024.05.104. [vi] Mark Riedl, “A Very Gentle Introduction to Large Language Models without the Hype,” Medium (blog), May 25, 2023, https://mark-riedl.medium.com/a-very-gentle-introduction-to-large-language-models-without-the-hype-5 f67941fa59e. [vii] David E. Burdette and Barbara E. Swartz, “Chapter 4 - Responsive Neurostimulation,” in Neurostimulation for Epilepsy, ed. Vikram R. Rao (Academic Press, 2023), 97–132, https://doi.org/10.1016/B978-0-323-91702-5.00002-5. [viii] Kimmelman and Tannock, 2018. [ix] Kimmelman and Tannock, 2018. [x] Simon Lohse, “Mapping Uncertainty in Precision Medicine: A Systematic Scoping Review,” Journal of Evaluation in Clinical Practice 29, no. 3 (April 2023): 554–64, https://doi.org/10.1111/jep.13789. [xi] Kimmelman and Tannock, “The Paradox of Precision Medicine.” [xii] Vogt and Hofmann, 1206. [xiii] Vogt and Hofmann, 1206. [xiv] Vogt and Hofmann, 1206. [xv] Vogt and Hofmann, 1207. [xvi] Vogt and Hofmann, 1207. [xvii] Vogt and Hofmann, 1207. [xviii] Vogt and Hofmann, 1210. [xix] Mehar Sahu et al., “Chapter Three - Artificial Intelligence and Machine Learning in Precision Medicine: A Paradigm Shift in Big Data Analysis,” in Progress in Molecular Biology and Translational Science, ed. David B. Teplow, vol. 190, 1 vols., Precision Medicine (Academic Press, 2022), 57–100, https://doi.org/10.1016/bs.pmbts.2022.03.002. [xx] Stefan Feuerriegel et al., “Causal Machine Learning for Predicting Treatment Outcomes,” Nature Medicine 30, no. 4 (April 2024): 958–68, https://doi.org/10.1038/s41591-024-02902-1. [xxi] Sunderland Baker et al., “Ethical Considerations in Closed Loop Deep Brain Stimulation,” Deep Brain Stimulation 3 (October 1, 2023): 8–15, https://doi.org/10.1016/j.jdbs.2023.11.001. [xxii] David Haslacher et al., “AI for Brain-Computer Interfaces,” 2024, 7, https://doi.org/10.1016/bs.dnb.2024.02.003. [xxiii] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 103–4; “Premarket Approval (PMA),” https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P100026. [xxiv] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 104. [xxv] Burdette and Swartz, 126. [xxvi] Sean L. Metzger et al., “A High-Performance Neuroprosthesis for Speech Decoding and Avatar Control,” Nature 620, no. 7976 (August 2023): 1037–46, https://doi.org/10.1038/s41586-023-06443-4. [xxvii] Hao Fang and Yuxiao Yang, “Predictive Neuromodulation of Cingulo-Frontal Neural Dynamics in Major Depressive Disorder Using a Brain-Computer Interface System: A Simulation Study,” Frontiers in Computational Neuroscience 17 (March 6, 2023), https://doi.org/10.3389/fncom.2023.1119685; Mahsa Malekmohammadi et al., “Kinematic Adaptive Deep Brain Stimulation for Resting Tremor in Parkinson’s Disease,” Movement Disorders 31, no. 3 (2016): 426–28, https://doi.org/10.1002/mds.26482. [xxviii] Young-Hoon Nho et al., “Responsive Deep Brain Stimulation Guided by Ventral Striatal Electrophysiology of Obsession Durably Ameliorates Compulsion,” Neuron 0, no. 0 (October 20, 2023), https://doi.org/10.1016/j.neuron.2023.09.034. [xxix] Nho et al. [xxx] Nho et al.; Erik Robinson, “Brain Implant at OHSU Successfully Controls Both Seizures and OCD,” OHSU News, accessed March 3, 2024, https://news.ohsu.edu/2023/10/25/brain-implant-at-ohsu-successfully-controls-both-seizures-and-ocd. [xxxi] Awuah et al., “Bridging Minds and Machines”; Haslacher et al., “AI for Brain-Computer Interfaces.” [xxxii] Awuah et al., “Bridging Minds and Machines.” [xxxiii] Sara Green, Barbara Prainsack, and Maya Sabatello, “The Roots of (in)Equity in Precision Medicine: Gaps in the Discourse,” Personalized Medicine 21, no. 1 (January 2024): 5–9, https://doi.org/10.2217/pme-2023-0097. [xxxiv] Green, Prainsack, and Sabatello, 7. [xxxv] Robyn Bluhm and Kirstin Borgerson, “An Epistemic Argument for Research-Practice Integration in Medicine,” The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine 43, no. 4 (July 9, 2018): 469–84, https://doi.org/10.1093/jmp/jhy009. [xxxvi] Vijay Mahant, “‘Right-to-Try’ Experimental Drugs: An Overview,” Journal of Translational Medicine 18 (June 23, 2020): 253, https://doi.org/10.1186/s12967-020-02427-4. [xxxvii] Michael S. Okun et al., “Deep Brain Stimulation in the Internal Capsule and Nucleus Accumbens Region: Responses Observed during Active and Sham Programming,” Journal of Neurology, Neurosurgery & Psychiatry 78, no. 3 (March 1, 2007): 310–14, https://doi.org/10.1136/jnnp.2006.095315. (shrink)

Given a Polish groupG, let$E(G)$be the right coset equivalence relation$G^{\omega }/c(G)$, where$c(G)$is the group of all convergent sequences inG. The connected component of the identity of a Polish groupGis denoted by$G_0$.Let$G,H$be locally compact abelian Polish groups. If$E(G)\leq _B E(H)$, then there is a continuous homomorphism$S:G_0\rightarrow H_0$such that$\ker (S)$is non-archimedean. The converse is also true whenGis connected and compact.For$n\in {\mathbb {N}}^+$, the partially ordered set$P(\omega )/\mbox {Fin}$can be embedded into Borel equivalence relations between$E({\mathbb {R}}^n)$and$E({\mathbb {T}}^n)$.

The purpose of this note is to study impulsive control and synchronization of memristor based chaotic circuits shown by Muthuswamy. We first establish a less conservative sufficient condition for the stability of memristor based chaotic circuits. After that, we discuss the effect of errors on stability. Meanwhile, we also discuss impulsive synchronization of two memristor based chaotic systems. Our results are more general and more applicable than the ones shown by Yang, Li, and Huang. Finally, several numerical examples are (...) given to show the effectiveness of our methods. (shrink)

It has been suggested that damage to anterior regions of the left hemisphere results in a dissociation in the perception and lexical activation of past-tense forms. Specifically, in a lexical-decision task in which past-tense primes immediately precede present-tense targets, such patients demonstrate significant priming for irregular verbs (spoke–speak), but, unlike control participants, fail to do so for regular verbs (looked–look). Here, this behavioral dissociation was first confirmed in a group of eleven patients with damage to the pars opercularis (BA 44) (...) and pars triangularis (BA 45) of the left inferior frontal gyrus (i.e., Broca's area). Two conditions containing word-onset orthographic–phonological overlap (bead–bee, barge–bar) demonstrated that the disrupted regular-verb priming was accompanied by, and covaried with, disrupted ortho-phonological priming, regardless of whether prime stimuli contained the regular inflectional rhyme pattern. Further, the dissociation between impaired regular-verb and preserved irregular-verb priming was shown to be continuous rather than categorical; priming for weak-irregular verbs (spent–spend) was intermediate in size between that of regular verbs and strong verbs. Such continuous dissociations grounded in ortho-phonological relationships between present- and past-tense forms are predicted by single-system, connectionist approaches to inflectional morphology and not predicted by current dual-system, rule-based models. Event-related potential data demonstrated that N400 priming effects were intact for both regular and irregular verbs, suggesting that the absence of significant regular-verb priming in the response time data did not result from a disruption of lexical access, and may have stemmed instead from post-lexical events such as covert articulation, segmentation strategies, and/or cognitive control. (shrink)

The California Verbal Learning Test-Second Edition, is a commonly used tool to assess episodic memory. This study analyzed learning and memory characteristics in a cognitively healthy Chinese population, as well as the effects of age, sex and education on CVLT-II factors. In total, 246 healthy people aged 20–80 years and 29 persons with multiple sclerosis were included in this study and completed the CVLT-II. Factors including total learning, learning strategy, serial position effects, short-delay free and cued recall, long-delay free and (...) cued recall, repetitions and intrusions during recall, hits and false positives of recognition, and total recognition discriminability were calculated. The effects of age, sex and education on these factors were analyzed using ANCOVA or independent two-sample t-tests and further confirmed by multiple regression analysis. The regression-based normative data were then computed by the equivalent scores method. Moreover, differences in learning and memory were compared between persons with MS and age-, sex- and education-matched healthy individuals. Most CVLT-II factors significantly differed between different age and education groups; in particular, better performance in total learning, recall, semantic clustering and recognition was observed in the younger and more educated groups than in the older and less educated groups. Male participants showed higher recency effect scores, more repetitions and fewer hits than female participants. Compared with healthy individuals, persons with MS showed extensive impairments in memory processes, such as learning, recall, learning strategy and recognition. These findings indicated that verbal learning and memory were highly dependent on age and educational level but not strongly affected by sex. The CVLT-II effectively assesses episodic memory impairment in the Chinese-speaking population. (shrink)

In previous research comparing the Context-driven Model with the Default Model of meaning processing, the former was preferred. It predicts that contexts play an exclusively decisive role in meaning processing, whereas the latter holds that the inference of literal meaning generally goes through, unless it is subsequently defaulted or cancelled by the context it is associated with. The Standardization Model, which we added to our experiments, highlights that implicatures are figured out from standardized forms typically based on the mutual background (...) belief and speaker’s intention. We tested whether Chinese people’s processing of the gradable adjective scale conformed more to the Context-driven Model, the Default Model, or the Standardization Model. The results demonstrated that the Standardization Model is the most acceptable among the three. The findings of this study, which is the first study using the experimental paradigm on Chinese gradable adjectives, highlighted a need for further studies to investigate the same questions with different languages and cultures. (shrink)

We establish a simple condition, based on the willingness to bet on events, under which two biseparable preferences have cardinally equivalent utilities.

Understanding learners’ translating self-efficacy belief helps predict their ability to cope and translation performance during their career. Despite this connection, the assessment of self-efficacy during learning has been largely overlooked in translation research. The purpose of this study was to develop and validate an instrument to examine belief in self-efficacy in a sample of Chinese translation learners. Scale items were collected and refined based on an expert-panel consensus opinion. Exploratory factor analysis and confirmatory factor analysis across two independent samples revealed (...) and validated a three-dimensional structure: efficacy in internal competence, efficacy in psycho-physical competence, and efficacy in external competence. These findings provide supporting evidence for scale applications in educating translators. (shrink)

Berikut ini diperkenalkan tiga buku yang ditulis oleh para dosen Sekolah Tinggi Filsafat dan Teologi Widya Sasana di Malang tentang bagaimana Gereja Katolik perlu menempatkan diri dalam ruang publik Indonesia. Fokus buku pertama, tulisan Prof. Dr. Armada Riyanto (2014), adalah ajaran sosial Gereja Katolik, jadi ajaran mengenai bagaimana Gereja Katolik memahami panggilannya dalam masyarakat yang sekaligus menjadi ruang publiknya. Sepintas alur buku ini dapat mem- bingungkan karena penulis suka melancong ke pelbagai bidang sam- pingan, apalagi ia tidak menjelaskan (...) susunan bukunya. Namun kekaya- an buku ini justru terletak dalam luasnya acuan, penjelasan pelbagai latar belakang, serta perhatian pada konteks-konteks ajaran sosial Gereja yang diangkat penulis. Dengan demikian pembaca dibantu dalam mencari bagaimana umat Katolik Indonesia dapat memberikan sum- bangannya bagi bangsanya dalam segala pergulatannya. Bagian kedua, mulai dari bab ke-10, memasuki situasi umat Katolik Indonesia sebagai minoritas yang sepertinya masih “kurang memiliki” (187). Bertolak dari catatan bahwa waktu Congregatio Missionis (Romo-romo CM) mengam-bil alih wilayah Jawa Timur dari romo-romo Yesuit hanya ada 40 umat Katolik Jawa tercatat (hal. 203), bab 11 menjelaskan kesulitan yang dialami Gereja Katolik sejak dari permulaan abad ke-19 dalam bergiat di Hindia Belanda. Namun kemudian dijelaskan bagaimana orang Katolik Jawa, di antara- nya Pak Kasimo, sebelum Kemerdekaan sudah berjuang sebagai nasionalis Indonesia tulen. Bagian ketiga, dimulai dari bab 12, membahas sifat dialogal ajaran sosial Gereja dalam pelbagai dimensi. Bahwa iman dan teologi Gereja secara hakiki bersifat dialogal merupakan kesadaran teologis (dan sosiologis) baru. Daripada hanya berpegang teguh pada suatu ajaran yang sudah membatu menjadi tradisi, lalu dibawa begitu saja ke dalam dunia, Gereja menyadari bahwa iman maupun teologinya selalu bergerak dalam medan masyarakat di mana Gereja berhadapan dengan segala macam pemikiran dan tanta-ngan. Dengan sifat dialogal dimaksud bahwa iman dan teologi Gereja mau tak mau terwujud dalam menghadapi tantangan-tantangan itu. Kekuatan buku Prof. Armada ini adalah bahwa ia menempatkan ajaran sosial Gereja yang pokok-pokoknya sudah sering diuraikan ke dalam pelbagai konteks, dengan implikasi-implikasi dan acuan pada pelbagai pengalaman Gereja. Pembaca menemukan banyak petunjuk bagaimana ajaran sosial Gereja Katolik dapat menjadi inspirasi bagi umat Katolik Indonesia. Ada juga beberapa kelemahan. Tidak ada daftar nama. Dan barangkali cakupan uraiannya terlalu luas. Misalnya uraian panjang lebar tentang paham Platon dan Aristoteles tentang keadilan sebenarnya kurang relevan, begitu pula uraian tentang perkembangan pemikiran filosofis tentang demokrasi. Padahal pertanyaan sangat relevan, yang muncul di banyak negara, bagaimana sebuah minoritas berpartisipasi dalam sistem demokrasi tidak didiskusilan. Mengapa fungsi suatu Partai Katolik di Indonesia tidak diangkat, padahal seku- rang-kurangnya sudah tiga kali menjadi debat besar dan panas dalam umat Katolik Indonesia: 1960 di zaman demokrasi terpimpin, 1971 sesudah pemilihan umum pertama di bawah presiden Suharto, dan 1999 di masa reformasi. Betul, persepsi “kemiskinan struktural” dibuka dengan Rerum Novarum (h. 24), tetapi istilah itu sendiri tidak ditemukan di dalamnya, melainkan berasal dari teologi pembebasan. Karena penulis menganggap “pluralisme” tak punya arti di luar “pluralitas,” penulis tidak masuk ke dalam kontroversi tajam tentang pluralisme di Indone- sia. Fatwa MUI tentang pluralisme tidak didiskusi-kan. Uraian panjang tentang pendidikan Katolik yang sangat optimis tinggal normatif. Padahal dalam kenyataan Gereja Katolik, juga di Indonesia, biasanya justru mempertahankan pegangan eksklusif atas pendidikan. Dalam kaitan ini seharusnya penolakan UU Sisdiknas — dengan keharusan memberikan pelajaran agama kepada para siswa sesuai dengan agama mereka — oleh sebagian besar penanggap Katolik didiskusikan. Namun kekurangan-kekurangan ini tidak menghilangkan bahwa buku ini amat memperkaya pustaka Katolik berbahasa Indonesia tentang panggilan Gereja, juga panggilan Gereja Indonesia, dalam masyarakat (Franz Magnis-Suseno, Guru Besar Ilmu Filsafat Emeritus, Sekolah Tinggi Filsafat Driyarkara, Jakarta). (shrink)

This paper addresses variable-time impulsive control for coordinated tracking problem in nonlinear multiagent systems. To make followers coordinately track the leader, a variable-time impulsive controller is designed. Under some well-selected conditions, the comparison system of variable-time impulsive tracking control system is constructed by employing B-equivalence method. And we theoretically demonstrate that the two systems have the same stability property. Coordinated tracking criteria of multiagent systems are obtained by considering the comparison system. Numerical simulation is also provided to illustrate the correctness (...) of theoretical results and the efficiency of the variable-time impulsive controller. (shrink)

This study focuses on two specific privacy policies, namely privacy assurance and personalization declaration. Specifically, we investigate how these distinct privacy policies affect customers’ privacy concerns and subsequent purchase responses. We have developed a conceptual model that addresses the independent effects of privacy assurance and personalization declaration, as well as the mechanism of these effects. Our model is grounded in motivation theory and supported by a field experiment and a controlled experiment. Our study demonstrates that privacy assurance that claims security (...) protection negatively affects customers’ purchase probability and purchase amount. By contrast, personalization declaration that addresses personalized benefits positively affects customers’ purchase probability and purchase amount. Privacy concerns significantly mediate the negative effects of privacy assurance on purchase responses and the positive effects of personalization declaration on purchase responses. Overall, our findings inform managers of how to deploy privacy policies to reduce customers’ privacy concerns and boost purchase responses. (shrink)

Adolescents have gradually become a vital group of interacting with social media recommendation algorithms. Although numerous studies have been conducted to investigate negative reactions that the dark side of recommendation algorithms brings to social media users, little is known about the resistance intention and behavior based on their agency in the daily process of encountering algorithms. Focusing on the concept of algorithm resistance, this study used a two-path model to investigate the algorithmic resistance of rural Chinese adolescents in their daily (...) use of short video apps. The findings revealed that the perceived threat to freedom, algorithmic literacy, and peer influence were positively associated with the resistance willingness and intention; while the independent psychology on algorithmic recommendations significantly weakened resistance willingness and intention. Furthermore, this study verified the mediating role of resistance willingness and intention between the above independent variables and resistance behavior. Additionally, the positive impact of resistance willingness on resistance intention was confirmed. In conclusion, this study offers a comprehensive approach to further understanding adolescents’ algorithmic resistance awareness and behavior by combining psychological factors, personal competency, and interpersonal influences, as well as two types of resistance reactions. (shrink)

Here algebraic Routley-Meyer semantics is addressed for two fuzzy versions of the logic of relevant implication R. To this end, two versions R t and R T of R and their fuzzy extensions FRt and FRT , respectively, are first discussed together with their algebraic semantics. Next algebraic Routley-Meyer semantics for these two fuzzy extensions is introduced. Finally, it is verified that these logics are sound and complete over the semantics.

Rehabilitation mobility has become a new demand and travel mode for people to pursue active health. A large number of tourists choose to escape the cold in warm places to improve their health every winter. In this study, we collected the health index data of Seasonal Affective Disorder tourists from western China before and after their cold escape in Hainan Island in winter, aiming to compare whether rehabilitating cold escape can improve the Quality of Life of SAD tourists by hierarchical (...) analysis. Compared with previous studies, this paper has the following contributions: Firstly, the study samples were accurately screened according to the pathogenesis of SAD tourists and the confounding factors were strictly controlled; Secondly, the observational experimental method was used to conduct inter-group and intra-group control studies on 695 samples, and the results were more objective and reliable. Thirdly, the effect of treatment on the quality of life of 397 tourists in the rehabilitation mobility group was quantitatively evaluated from three factors including age, gender and sunshine exposure level by multivariate analysis of variance. Research results show that the rehabilitation environment brought by rehabilitation activities can help improve the health status of tourists. Therefore, this paper proposes the concept of “Tourism Therapy” and constructs a theoretical framework. The conclusion of this paper provides a scientific basis and reference for the study of tourism healing as a non-medical alternative therapy. (shrink)

Objectives: Athlete burnout is a crucial concern affecting the development and athletic performance of young weightlifters. To reduce or relieve the prevalence of athlete burnout, this study examined the relationship across social support, sports motivation, mental toughness, and athlete burnout in weightlifters.Methods: A total of 315 weightlifters aged 17–28 years old from Sichuan, Chongqing, and Shanxi in China participated in this survey. The Perceived Available Support in Sport Questionnaire, Sports Motivation Questionnaire, Sports Mental Toughness Questionnaire, and Athlete Burnout Questionnaire were (...) used in this study. SPSS Statistics 19.0, AMOS 21.0, and PROCESS 3.0 macro were used to analyze the collected data.Results: The results indicated that weightlifters’ social support could negatively significantly affect athlete burnout [beta = −0.398; 95% confidence interval : −0.3699, −0.2184; P < 0.05) via mental toughness and sports motivation. The mediation analysis revealed that they had partial mediating effect, including three paths: First, social support had a direct effect on athlete burnout ; second, sport mental toughness had a mediating effect on athlete burnout ; and finally, sports motivation had a mediating effect on athlete burnout.Conclusion: The findings revealed that social support could inhibit or prevent athlete burnout via mental toughness and sports motivation; thus, to decrease or relieve the prevalence of burnout in weightlifters, it is an important solution to enhance their social support. (shrink)